ea0038p147 | Neoplasia, cancer and late effects | SFEBES2015
Rahman Habibur
, Gilligan Lorna
, Hewitt Anne-Marie
, Morton Dion
, Foster Paul
Steroid sulphatase (STS) liberates sulphated oestrogens into their active forms. In the colon, evidence suggests that although initially pro-apoptotic in healthy mucosa, once malignancy occurs, oestrogens may stimulate colorectal cancer (CRC) proliferation. Moreover, greater intratumoural oestrogen synthesis is negatively associated with survival outcomes in CRC patients. However, little is known about oestrogen metabolism pathways in CRC, and whether alterations in local oest...